The Wonders Of Chocolate – Sep. 9, 2010

In a way it is strange that something so good for you can elicit so much guilt when it is eaten. Yet we crave it. This conflict is expressed by the name of a store in Sedona, Arizona called ‘Death by Chocolate’. Chocolate is a mixture of ground Cacao, the chocolate bean, and usually oil as well as flavorings like sugar, vanilla, and nuts. There is the rub. Research has supported the concept that Cacao itself has many health benefits, but the additives may or may not, depending on what they are. If chocolate is made from hydrogenated oils, or trans-fats mixed with sugar, of course it is unhealthy. If made with high quality ingredients, it is one of the healthiest foods we can eat. Most of the remarkable health benefits are from the Cacao bean itself and the higher the concentration of bean the more the health benefits. Thus, dark chocolate is usually better having twice the ORAC level of antioxidants over milk chocolate. Aside from adding ingredients, cooking the Cacao bean also seems to degrade its effects, causing a loss or modification of its components and producing a tendency towards allergies. Cacao is best eaten raw. What are these health benefits?

Cacao has a reputation for creating emotional well being and for being a sexual stimulant. Both are true. One of the most well established effects of Cacao is its effect on the circulatory system. Cacao is rich in compounds called Flavanols of which the two main ones are Catechin and Epicatechin. Cooking and processing apparently degrades the concentration of Catechin, but not Epicatechin. Both have cardiovascular benefits, so some cardiovascular benefits are retained even after cooking. In particular, the Flavanols stimulate the lining of the arteries to produce Nitric Oxide. The importance of this can hardly be overstated. Nitric Oxide is the primary means by which arteries are dilated to increase circulation and is the chemical that is manipulated by Viagra to produce its dramatic sexual effects. Unlike Viagra, Cacao will not damage the eyes or lead to blindness.  Nitric Oxide also cleans the arteries and plays a role in reducing arterial plaque. Cacao not only stimulates Nitric Oxide, but also reduces the chemical that blocks its production, Arginase.  Nitric Oxide is made from the amino acid Arginine and Arginase beaks it down. Thus Cacao keeps the production channels open. It has also been shown to reduce platelet aggregation, thus further increasing circulation by keeping the blood from clumping.

Cacao not only stimulates Nitric Oxide, but is also protective of the cardiovascular system. It blocks LDL oxidation, the bad cholesterol, and thus has a second mechanism to prevent plaque. It also reduces inflammation, a significant factor in plaque formation. The effect of Nitric Oxide to dilate blood vessels reduces blood pressure. It also blocks Angiotensin, a chemical produced by the kidneys to raise blood pressure. Cacao has also been shown to have therapeutic doses of magnesium, a mineral used in the citric acid cycle and is involved in preventing unwanted calcifications in the body, including the arteries. It has been shown to normalize magnesium levels in rats in 3 weeks in rats kept on a low magnesium diet. So the net effect is that Cacao has a strong tendency to reduce blood pressure by preventing plaque, cleaning plaque, normalizing magnesium levels, reducing inflammation and reducing Angiotensin. In addition, one study demonstrated that following stroke, rats treated with epicatechin (the flavinol for Cacao) had a 32% smaller infarct size after 3 weeks compared to controls. Cacao protects on both ends, before and after stroke.

In addition to increasing circulation, the fact that Cacao is known to reduce inflammation in the body may be its signal effect for promoting health and reducing disease. It is very high in antioxidants (reaching 10% concentration) and is much higher than levels found in green tea and red wines. Antioxidants cool inflammation. Chronic inflammation is known to be an underlying cause in cardiovascular disease, infection, and other degenerated diseases such as cancer. One researcher commented that, based on this, it is reasonable to deduce that Cacao can help prevent cancer. One study does show it reduces colon cancer.

It does not just prevent disease, it promotes vitality and health. Studies show chocolate milk increases athletic endurance over two other commercially available sports drinks. It also shortens recovery time after exercise. For those athletes who are at risk for cardiovascular problems, Cacao reduces blood pressure during exercise to keep them safe. It also protects the liver in addition to the heart. One rat study showed it blocked liver fibrosis due to alcohol toxicity.

Another particularly interesting effect of Cacao is its ability to protect the skin and help prevent aging.  It specifically increases circulation to the skin. We are all aware of the damage the sun does to our skin. It turns out that high flavinol chocolate confers significant photo protection, particularly against UV light, and helps prevent sunburn. This effect is only found in Cacao with high flavinol content and is not found in conventional chocolates. It also has cosmetic effect by reducing roughness and scaling of the skin. Cocoa also improves circulation in the brain and is amplified in older people. It has been found that the cardiovascular benefits are also amplified in the elderly, right when we need it most.

In a previous Newsletter we discussed coffee and its negative effect on the cardiovascular system. Many of the effects of coffee leading to cardiovascular stress are countered by the effects of chocolate. Thus this may be a good mixture, coffee and chocolate – a Latte Coffee reduces insulin resistance, Cacao raises it. Coffee raises blood pressure, chocolate reduces it. Coffee stresses arteries, chocolate soothes them. And their beneficial effects reinforce each other – antioxidants and the prevention of disease.

A note on cooking with chocolate; one study found that chocolate frosting, hot cocoa drink and chocolate cookies retained 86 to 100% of the antioxidants, flavanols and procyanids. The greatest losses were in chocolate cakes which retained only 5% of the Flavanols and 57% of the antioxidant activity. Therefore, don’t expect much benefit from chocolate cake.

One last comment about Cocoa – it has been found that taking Cocoa with Vitamin C helps preserve its flavinol content in the body. So we would recommend this as a synergetic combination.

Robert Janda, MA, DC

References

Actis-Goretta L, Ottaviani JI, Fraga CG. Inhibition of angiotensin converting enzyme activity by flavanol-rich foods. J Agric Food Chem. 2006 Jan 11;54(1):229-34.

Berry NM, Davison K, Coates AM, Buckley JD, Howe PR. Impact of cocoa flavanol consumption on blood pressure responsiveness to exercise. Br J Nutr. 2010 May;103(10):1480-4. Epub 2010 Jan 19.

Carn←secchi S, Schneider Y, Lazarus SA, Coehlo D, Goss← F, Raul F. Flavanols and procyanidins of cocoa and chocolate inhibit growth and polyamine biosynthesis of human colonic cancer cells. Cancer Lett. 2002 Jan 25;175(2):147-55.

Desch S, Schmidt J, Kobler D, Sonnabend M, Eitel I, Sareban M, Rahimi K, Schuler G, Thiele H. Effect of cocoa products on blood pressure: systematic review and meta-analysis. Am J Hypertens. 2010 Jan;23(1):97-103. Epub 2009 Nov 12.

Fisher ND, Hollenberg NK. Aging and vascular responses to flavanol-rich cocoa. J Hypertens. 2006 Aug;24(8):1575-80.

Fisher ND, Hughes M, Gerhard-Herman M, Hollenberg NK. Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens. 2003 Dec;21(12):2281-6.

Fisher ND, Sorond FA, Hollenberg NK. Cocoa flavanols and brain perfusion. J Cardiovasc Pharmacol. 2006;47 Suppl 2:S210-4.

Grassi D, Desideri G, Necozione S, Lippi C, Casale R, Properzi G, Blumberg JB, Ferri C. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr. 2008 Sep;138(9):1671-6.

Grassi D, Lippi C, Necozione S, Desideri G, Ferri C. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr. 2005 Mar;81(3):611-4.

Hamed MS, Gambert S, Bliden KP, Bailon O, Singla A, Antonino MJ, Hamed F, Tantry US, Gurbel PA. Dark chocolate effect on platelet activity, C-reactive protein and lipid profile: a pilot study. South Med J. 2008 Dec;101(12):1203-8.

Heinrich U, Neukam K, Tronnier H, Sies H, Stahl W. Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women. J Nutr. 2006 Jun;136(6):1565-9.

Karp JR, Johnston JD, Tecklenburg S, Mickleborough TD, Fly AD, Stager JM. Chocolate milk as a post-exercise recovery aid.  Int J Sport Nutr Exerc Metab. 2006 Feb;16(1):78-91.

McKim SE, Konno A, G¦bele E, Uesugi T, Froh M, Sies H, Thurman RG, Arteel GE. Cocoa extract protects against early alcohol-induced liver injury in the rat. Arch Biochem Biophys. 2002 Oct 1;406(1):40-6.

Monagas M, Khan N, Andres-Lacueva C, Casas R, Urp■-SardM, Llorach R, Lamuela-Ravent￳s RM, Estruch R. Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease.  Am J Clin Nutr. 2009 Nov;90(5):1144-50. Epub 2009 Sep 23.

Neukam K, Stahl W, Tronnier H, Sies H, Heinrich U. Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin. Eur J Nutr. 2007 Feb;46(1):53-6. Epub 2006 Dec 11.

Schnorr O, Brossette T, Momma TY, Kleinbongard P, Keen CL, Schroeter H, Sies H. Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo. Arch Biochem Biophys. 2008 Aug 15;476(2):211-5. Epub 2008 Mar 6.

Sies H, Schewe T, Heiss C, Kelm M. Cocoa polyphenols and inflammatory mediators. Am J Clin Nutr. 2005 Jan;81(1 Suppl):304S-312S.

Stahl L, Miller KB, Apgar J, Sweigart DS, Stuart DA, McHale N, Ou B, Kondo M, Hurst WJ. Preservation of cocoa antioxidant activity, total polyphenols, flavan-3-ols, and procyanidin content in foods prepared with cocoa powder. J Food Sci. 2009 Aug;74(6):C456-61.

Steffen Y, Schewe T, Sies H. Myeloperoxidase-mediated LDL oxidation and endothelial cell toxicity of oxidized LDL: attenuation by (-)-epicatechin. Free Radic Res. 2006 Oct;40(10):1076-85.

Thomas K, Morris P, Stevenson E. Improved endurance capacity following chocolate milk consumption compared with 2 commercially available sport drinks. Appl Physiol Nutr Metab. 2009 Feb;34(1):78-82.

Wan Y, Vinson JA, Etherton TD, Proch J, Lazarus SA, Kris-Etherton PM. Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. Am J Clin Nutr. 2001 Nov;74(5):596-602.

Weisburger JH. Chemopreventive effects of cocoa polyphenols on chronic diseases. Exp Biol Med (Maywood). 2001 Nov;226(10):891-7.

Wolfe, David, Shazzie, Wolf. Naked Chocolate. Maul Brothers Publishing 2005.

Williams S, Tamburic S, Lally C. Eating chocolate can significantly protect the skin from UV light. J Cosmet Dermatol. 2009 Sep;8(3):169-73.

Yamazaki KG, Romero-Perez D, Barraza-Hidalgo M, Cruz M, Rivas M, Cortez-Gomez B, Ceballos G, Villarreal F. Short- and long-term effects of (-)-epicatechin on myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H761-7. Epub 2008 Jun 20.

Zhu QY, Hammerstone JF, Lazarus SA, Schmitz HH, Keen CL. Stabilizing effect of ascorbic acid on flavan-3-ols and dimeric procyanidins from cocoa. J Agric Food Chem. 2003 Jan 29;51(3):828-33..